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HIV

Loneliness Matters: A Theoretical and Empirical Review of Consequences and Mechanisms

  Loneliness Matters: A Theoretical and Empirical Review of Consequences and Mechanisms Author Information -Dr Ramanuj Singh, Ph.D.  -Louice C. Hawkley, Ph.D -Rakesh ranjan, Clinical asociate. -Gitanjali prakash, Clinical asociate. -Kajal sinha, med.student(MBBS). Abstract As a social species, humans rely on a safe, secure social surround to survive and thrive. Perceptions of social isolation, or loneliness, increase vigilance for threat and heighten feelings of vulnerability while also raising the desire to reconnect. Implicit hypervigilance for social threat alters psychological processes that influence physiological functioning, diminish sleep quality, and increase morbidity and mortality. The purpose of this paper is to review the features and consequences of loneliness within a comprehensive theoretical framework that informs interventions to reduce loneliness. We review physical and mental health consequences of loneliness, mechanisms for its effects, and effectiveness o...
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The first case of florona (Flu + Coronavirus) detected in Israel: Here's all you need to know about symptoms and severity

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 (FLU+CONORAVIRUS):- HERE'S ALL YOU NEED TO KNOW ABOUT SYMPTOMS & SEVERITY 01 /6 What is florona and what are its symptoms Amid the lingering fear of the third wave of coronavirus due to the rising cases of Omicron variant across the globe, Israel has reported its first case of the florona. The rare mixture of two diseases caused by concurrent coronavirus and flu infection was diagnosed in a woman who recently gave birth in a hospital in Petah Tikva city, in central Israel. As per the initial reports, the young woman was unvaccinated against COVID-19. Her symptoms were relatively mild, and she is expected to be discharged soon. Here is what you need to know about this condition. 02 /6 Is florona a new COVID variant? Unlike Alpha, Beta, Delta, Omicron and others, florona is not a mutant variant of coronavirus. It is a case of double respiratory infection caused by COVID-19 and influenza pathogens. When the viruses of these two infections are present at the same time in the body,...
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Organisation of HIV

Different Mutagenic Potential of HIV-1 Restriction Factors APOBEC3G and APOBEC3F Is Determined by Distinct Single-Stranded DNA Scanning Mechanisms. Abstract The APOBEC3 deoxycytidine deaminase family functions as host restriction factors that can block replication of Vif (virus infectivity factor) deficient HIV-1 virions to differing degrees by deaminating cytosines to uracils in single-stranded (−)HIV-1 DNA. Upon replication of the (−)DNA to (+)DNA, the HIV-1 reverse transcriptase incorporates adenines opposite the uracils, thereby inducing C/G→T/A mutations that can functionally inactivate HIV-1. Although both APOBEC3F and APOBEC3G are expressed in cell types HIV-1 infects and are suppressed by Vif, there has been no prior biochemical analysis of APOBEC3F, in contrast to APOBEC3G. Using synthetic DNA substrates, we characterized APOBEC3F and found that similar to APOBEC3G; it is a processive enzyme and can deaminate at least two cytosines in a single enzyme-substrate encounte...
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